Synmatrix-CM

Cardiomyocyte Maturation Matrix for hiPSC-CMs

A defined ECM-mimetic photocrosslinkable hydrogel matrix designed to support functional maturation, alignment, and contractile activity of human iPSC-derived cardiomyocytes in 3D culture systems.

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Key Features

Promotes maturation: supports structural and functional maturation of hiPSC-derived cardiomyocytes.

Enhances contractility: enables stable and measurable spontaneous beating behavior.

ECM-mimetic environment: provides a physiologically relevant 3D microenvironment for cardiac cells.

Photocrosslinkable control: allows tuning of matrix stiffness and geometry for cardiac applications.

Reproducible system: supports consistent and standardised cardiac culture workflows.

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Typical Applications

3D culture of hiPSC-derived cardiomyocytes

Cardiac tissue maturation and functional studies

Engineered heart tissue (EHT) models

Cardiac disease modelling

Drug response and cardiotoxicity assessment

Integration with heart-on-chip and microphysiological systems

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Specifications

Property	Details
Product name	Synmatrix-CM
Product type	Defined ECM-mimetic photocrosslinkable hydrogel
Form	Solid (lyophilized / sponge-like)
Appearance	White to off-white
Application	Cardiomyocyte culture and cardiac 3D systems
Crosslinking	Photoinitiated
Wavelength	365–405 nm
Preparation	Dissolution in aqueous buffer
Storage	Frozen recommended

 

Validated Systems

Synmatrix-CM is designed for cardiac 3D culture systems, including:

hiPSC-derived cardiomyocytes

Engineered heart tissues (EHTs)

Cardiac microtissues and spheroids

Heart-on-chip and contractility assay platforms

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Preparation & Use

1. Photoinitiator preparation: prepare sterile LAP solution (0.2% w/v), filter sterilize, store at 4 °C protected from light.

2. Hydrogel preparation: dissolve Synmatrix-CM with LAP solution and DPBS to 6% (w/v), stir under light protection until clear.

3. Gel formation: mix with cardiomyocytes, dispense, and crosslink under 405 nm light (~30 s).

4. Culture setup: wash with DPBS, replace with culture medium, incubate under standard conditions.

Safety

Use appropriate PPE. Avoid inhalation, ingestion, and contact with skin or eyes. Protect from light. Dispose according to local regulations. For research use only.

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What’s Included

Synmatrix-CM hydrogel precursor

Quick-start protocol