GelMA (75% Substitution）

GelMA (Gelatin Methacrylate)

Green-chemistry–derived, photocrosslinkable hydrogel precursor widely used in 3D cell culture, bioprinting, and organ-on-chip applications. Our GelMA is synthesized with an optimized process that eliminates residual methacrylic anhydride, resulting in very low cytotoxicity and excellent biocompatibility. The material’s tunable mechanics and stress-relaxation behavior make it an ideal mimic of native extracellular matrix (ECM). For research use only.

Key Features

• Green synthesis: no detectable methacrylic anhydride residue, minimizing cytotoxic effects.
• Tunable mechanics: elastic modulus and stress-relaxation adjustable to replicate ECM properties.
• High biocompatibility: supports a broad range of primary cells, stem cells, and organoids.
• Photocrosslinkable: compatible with LAP and Irgacure 2959 under 365–420 nm light.
• Validated across systems: extensively tested for reproducible cell culture outcomes.

Molecular Substitution Level

Available in defined degrees of substitution (DoS) for precise control of hydrogel stiffness and bioactivity:

• GelMA-75%: high substitution level (~75%). Provides stronger mechanical properties and slower degradation. Suitable for muscle, cardiac, and load-bearing tissue models.
• Other DoS options available on request (e.g., ~50% for softer matrices or ~90% for stiffer scaffolds).

Specifications

Typical Applications

• 3D culture and encapsulation of mammalian cells
• Organoid development and passaging
• 3D bioprinting (extrusion, DLP, SLA)
• Organ-on-chip and tissue-on-chip platforms
• Regenerative medicine research (cardiac, skeletal muscle, cartilage)